Figure 5.

TO does not reverse the immature lung gene expression profile induced by DH. (A) Rabbit lung gene expression was correlated to that of published mouse lung development data (24). While there was a high degree of correlation at E18 and beyond, DHTO and DH lung were more highly correlated at E12, E14 and E16 than control lung. The colors used in this panel are translucent with olive indicating DH, TO and DHTO and orange DH and DHTO. (B) The average gene expression profile of each mouse lung age was plotted on the same matrix as the previous fetal rabbit lung matrix. Over the course of lung development, gene expression in region 1 decreases and gene expression in region 3 increases. Gene expression in region 2 is overall unchanged although the pattern changes.