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. 2015 Sep 18;23(3):469–483. doi: 10.1038/cdd.2015.114

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Copyright © 2016 Macmillan Publishers Limited

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MNK1 mediates TNFα-induced inhibition of cell migration and capillary tube formation in ECs. The effect of TNFα on HUVEC network formation (a and b) and cell migration (c) in vitro. HUVECs were subjected to capillary tube formation and wound healing assays during TNFα treatment as described in the Materials and Methods. Representative images in capillary tube formation assays are shown in (a). (b and c) All the results are mean±S.D. (n=6). (d) Knockdown efficiency of MNK1 or PML in aliquots of (e) and (f). (e) The effect of MNK1 or PML knockdown on TNFα-mediated inhibition of EC migration. The left panel shows representative images of wound healing assays and the right panel shows cell migration rates. (f) The effect of MNK1 or PML knockdown on TNFα-mediated inhibition of in vitro capillary network formation. Representative images are shown in the left panel and the numbers of branches in each field were counted and quantified as shown in the right panel. (e and f) The statistical results are mean±S.D. (n=6)