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. 2015 Oct 16;23(3):521–530. doi: 10.1038/cdd.2015.120

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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SC apoptosis is correlated with p53 activation. The activation of P53 was investigated in SCs at E15 in control (Cre-) (a, c) and SCMdm2^−/− (b, d) testes through double p53/AMH immunostaining. Upper panel represents a global view of a testis section and lower panel a higher magnification of testicular cords. No p53 was observed in control SCs (a, c), while many p53-positive cells (brown) were detected in cord-like structures in SC-Mdm2^−/− (b, d). Interestingly, most were clearly positive for AMH staining (purple) as well. Arrowheads point to p53-negative SCs (c and d) and arrows point to p53-positive SCs (d: double positive). Bars represent 10 μm