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. 2015 Oct 16;23(3):521–530. doi: 10.1038/cdd.2015.120

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Maintenance of Leydig cells in absence of SCs. 3βHSD staining (brown) in E15, E18, P1 and adult controls (Cre-) (a to h) and SC-Mdm2^−/− (i to p) testes detected Leydig cells. Left panels (low magnification: a, c, e, g for Cre- and i, k, m, o for SC-Mdm2^−/−) represent an overview of a representative section of the testes (cartography). Right panels represent high magnifications (b, d, f, h for Cre- and i, k, m, o for SC-Mdm2^−/−). Numerous Leydig cells were retrieved in both genotypes at all ages studied. Bars represent 10 μm