Table 5.
In vitro aerosol dispersion performance as DPIs. (n=3, mean ± standard deviation)
| Powder Formulation Composition (molar ratio) |
Spray Drying Pump Rate (%) |
Emitted Dose (%) |
Fine Particle Fraction (%) |
Respirable Fraction (%) |
MMAD (µm) |
GSD |
|---|---|---|---|---|---|---|
| SD DMF | High) (100%) |
85.18±5.51 | 17.07±4.72 | 61.28±21.61 | 7.59±1.55 | 1.89±0.16 |
| SD D-MAN | Low (25%) |
89.57±4.05 | 29.56±3.83 | 43.26±6.02 | 7.24±1.68 | 2.81±0.20 |
| SD D-MAN | Med (50%) |
81.55±8.59 | 26.34±3.46 | 37.60±4.28 | 8.56±1.34 | 2.84±0.18 |
| SD D-MAN | High (100%) |
85.89±10.38 | 49.46±6.93 | 76.15±6.01 | 3.89±0.34 | 1.98±0.32 |
| DMF:D-MAN 50:50 |
Low (25%) |
69.60±10.52 | 33.63±2.06 | 49.59±5.47 | 5.32±0.81 | 2.59±0.15 |
| DMF:D-MAN 50:50 |
Med (50%) |
64.59±7.35 | 13.64±1.94 | 22.33±2.41 | 18.36±1.87 | 3.73±0.18 |
| DMF:D-MAN 50:50 |
High (100%) |
71.64±15.20 | 42.56±1.32 | 74.73±8.82 | 3.67±0.59 | 2.01±0.13 |
| DMF:D-MAN 80:20 |
Low (25%) |
84.08±10.30 | 22.63±0.82 | 32.10±1.19 | 10.92±0.74 | 3.69±0.18 |
| DMF:D-MAN 80:20 |
Med (50%) |
88.70±3.10 | 29.82±4.53 | 48.96±8.11 | 6.86±1.25 | 2.46±0.17 |
| DMF:D-MAN 80:20 |
High (100%) |
95.66±4.69 | 34.48±1.42 | 62.70±0.81 | 5.56±0.26 | 2.38±0.05 |
| DMF:D-MAN 90:10 |
Low (25%) |
85.17±5.61 | 23.15±1.76 | 32.89±3.83 | 11.15±1.84 | 3.09±0.15 |
| DMF:D-MAN 90:10 |
Med (50%) |
87.74±6.30 | 24.12±2.43 | 45.23±3.79 | 7.85±0.92 | 2.65±0.14 |
| DMF:D-MAN 90:10 |
High (100%) |
87.01±7.58 | 24.15±0.83 | 51.70±0.77 | 7.86±0.33 | 2.34±0.07 |