Figure 4.

Effect of single IT injection of salicylate 100 µg/10 µl, Tropisetron 100 µg/10 µl and 150 µg/10 µl on paw-withdrawal threshold after themal (heat) stimulus . Data are expressed as means ± SEM withdrawal threshold (second). The mean withdrawal threshold is significantly increased after administration of salicylate and tropisetron 100 µg/10 µl compared to saline-treated animals and to stimulation before treatment, * statistical difference with saline-treated groups (P < 0.05), $ statistical defference with pre-treatment (P < 0.05). #, statistical difference with control groups (P < 0.001).