Figure 1.

Wrinkle reduction documented by all the three parameters described in (A) diagram of skin contours and data collection; (B) Ra (average roughness in micrometers); (C) Rz (average contour of all maxima [between peaks and hollows] on the profile length; and [D] Rt [average amplitude in micrometers of the five highest maxima {between peaks and hollows}] on the profile length).

Note: The wrinkle reduction seen at day 56 was statistically significant for all the three parameters (P<0.05).

Abbreviation: D, day.