Table 3.
Results of pharmacogenetic testing
| Hospital admissions | Pharmacogenetic profil
|
||||
|---|---|---|---|---|---|
| CYP2C19 | CYP2C9 | VKORC1 | CYP2D6 | CYP3A4/5 | |
|
| |||||
| Cases | |||||
| High | ENM | ENM | HWS | ENM | PM |
| High | ENM | ENM | IWS | RM | ENM |
| High | RM | ENM | IWS | ENM | PM |
| High | RM | ENM | NWS | ENM | ENM |
| High | RM | ENM | HWS | ENM | ENM |
| High | RM | ENM | IWS | ENM | IM |
| Controls | |||||
| Low | ENM | ENM | NWS | ENM | ENM |
| Low | IM | ENM | NWS | IM | ENM |
| Low | IM | ENM | NWS | ENM | ENM |
| Low | IM | ENM | NWS | ENM | ENM |
| Low | IM | ENM | NWS | IM | ENM |
| Low | IM | IM | IWS | ENM | ENM |
Abbreviations: ENM, extensive/normal metabolizer; HWS, high warfarin sensitivity; IM, intermediate metabolizer; IWS, increased warfarin sensitivity; NWS, normal warfarin sensitivity; PM, poor metabolizer; RM, rapid metabolizer.