Table 1. Distribution of the genotypes and alleles of endothelin-1 (EDN1) and endothelin receptor type A (EDN RA) polymorphisms in NTG and HTG and healthy controls.
| Gene/Polymorphism | Genotype | P value | Allele | P value | |||
|---|---|---|---|---|---|---|---|
| EDN-1: K198N | |||||||
| |
GG |
TT |
GT |
0.39 |
allele G |
allele T |
0.125 |
| NTG |
107 |
7 |
46 |
|
260 |
60 |
|
| HTG |
91 |
4 |
29 |
|
211 |
37 |
|
| Controls |
125 |
3 |
37 |
|
287 |
43 |
|
| EDN RA: C1222T | |||||||
| |
CC |
TT |
CT |
0.13 |
allele C |
allele T |
0.240 |
| NTG |
56 |
24 |
79 |
|
191 |
129 |
|
| HTG |
44 |
16 |
64 |
|
152 |
96 |
|
| Controls |
55 |
39 |
71 |
|
181 |
149 |
|
| EDN RA: C70G | |||||||
| |
CC |
GG |
CG |
0.008 |
allele C |
allele G |
0.390 |
| NTG |
27 |
44 |
89 |
|
143 |
177 |
|
| HTG |
21 |
36 |
67 |
|
109 |
139 |
|
| Controls |
48 |
51 |
63 |
|
159 |
165 |
|
| EDN RA: G231A | |||||||
| |
GG |
AA |
GA |
0.26 |
allele G |
allele A |
0.210 |
| NTG |
83 |
6 |
71 |
|
237 |
83 |
|
| HTG |
65 |
5 |
54 |
|
119 |
59 |
|
| Controls | 81 | 15 | 69 | 231 | 99 | ||