Table 2.
Basic characteristics of SNPs in the enrolled population
| SNPs | Chromosomes | Position | Gene | Allele | Risk of COPD
|
Risk of COPD with PH
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HWE-P | OR | 95% CI | Allele, P-value | HWE-P | OR | 95% CI | Allele, P-value | |||||
| rs2362290 | 2q37.1 | 233916724 | TRPM8 | AG | 0.061 | 1.03 | 0.85–1.24 | 0.781 | 0.291 | 0.8 | 0.60–1.07 | 0.130 |
| rs9789675 | 2q37.1 | 233916914 | TRPM8 | AG | 0.494 | 1.17 | 0.91–1.51 | 0.241 | 0.453 | 0.63 | 0.42–0.97 | 0.034* |
| rs9789398 | 2q37.1 | 233916979 | TRPM8 | CT | 0.922 | 1.33 | 1.01–1.74 | 0.040* | 0.609 | 1.59 | 1.03–2.44 | 0.034* |
| rs1003540 | 2q37.1 | 233917239 | TRPM8 | AG | 0.065 | 0.99 | 0.82–1.19 | 0.912 | 0.394 | 1.28 | 0.96–1.70 | 0.394 |
| rs1004478 | 2q37.1 | 233917250 | TRPM8 | CG | 0.06 | 0.96 | 0.80–1.16 | 0.683 | 0.182 | 1.21 | 0.91–1.62 | 0.194 |
Note:
*
P<0.05 indicates statistical significance.
Abbreviations: CI, confidence interval; HWE-P, P-value of Hardy–Weinberg equilibrium; OR, odds ratio; PH, pulmonary hypertension; SNP, single nucleotide polymorphism; TRPM8, transient receptor potential cation channel subfamily M member 8.