. 2016 Oct 20;12(10):e1006371. doi: 10.1371/journal.pgen.1006371

Table 3. SNPs identified in candidate gene exon analysis.

The genotype is coded for the risk increasing allele, which is the first one mentioned (e.g., A in A/C). The discovery test of ARHI in GERA non-Hispanic whites was two-sided^#, and all replication tests were one-sided. There are no estimates for African American cases SDS/SRT, as the sample size was too small. OR, odds ratio (for case/control phenotypes); Effect, effect size estimate (for SDS/SRT phenotypes); Freq, frequency of the risk increasing allele; SRT, speech reception threshold; SDS, speech discrimination score.

		rs2877561 (A/C)–exon 2 all transcripts, synonymous, ILDR1				rs9493627 (A/G)–exon 11 of NM_172105 & NM_004100, exon 10 of NM_172103, missense, EYA4
Phenotype	Group	Freq	OR/Effect	P	r_info²	Freq	OR/Effect	P	r_info²
ARHI ICD-9 case/control	GERA non-Hispanic white^#	0.281	1.090	6.2x10^-5	0.98	0.317	1.083	0.00011	1.00
	GERA Latino	0.347	0.930	0.16	0.99	0.313	1.217	0.0037	1.00
	GERA East Asian	0.092	1.099	0.26	0.96	0.338	1.009	0.46	1.00
	GERA African American	0.190	1.141	0.20	0.96	0.505	1.176	0.095	1.00
	GERA Latino, East Asian, and African Americans replication meta-analysis	-	0.988	0.42	-	-	1.129	0.0080	-
ARHI case/control by self-report	UK Biobank	0.271	1.037	0.00057	0.98	0.319	1.025	0.0095	1.00
Cases SRT, modeled as sqrt(SRT), higher is worse hearing	GERA non-Hispanic white	0.301	0.089	0.0055	0.98	0.329	0.033	0.16	1.00
	GERA Latino	0.334	-0.096	0.75	0.99	0.372	-0.140	0.89	1.00
	GERA East Asian	0.070	-0.187	0.71	0.96	0.443	0.054	0.32	1.00
	GERA African American	-	-	-	0.96	-	-	-	1.00
	GERA Meta-analysis of all	-	0.077	0.012	-	-	0.021	0.24	-
Controls SRT	GERA non-Hispanic white	0.283	0.058	0.027	0.98	0.332	0.041	0.072	1.00
	GERA Latino	0.282	0.275	0.0011	0.99	0.350	-0.075	0.75	1.00
	GERA East Asian	0.094	0.189	0.11	0.96	0.312	0.157	0.056	1.00
	GERA African American	0.196	-0.279	0.93	0.96	0.546	0.137	0.27	1.00
	GERA Meta-analysis of all	-	0.076	0.0032	-	-	0.044	0.046	-
Overall SRT	GERA Meta-analysis of all	-	0.076	0.00019	-	-	0.034	0.041	-
Cases SDS, modeled as log(100-SDS+1), higher is worse hearing	GERA non-Hispanic white	0.303	0.045	0.065	0.98	0.332	-0.015	0.70	1.00
	GERA Latino	0.344	0.035	0.39	0.99	0.368	-0.209	0.98	1.00
	GERA East Asian	0.078	-0.135	0.65	0.96	0.449	0.318	0.0035	1.00
	GERA African American	-	-	-	0.96	-	-	-	1.00
	GERA Meta-analysis of all	-	0.044	0.070	-	-	-0.012	0.67	-
Controls SDS	GERA non-Hispanic white	0.284	0.048	0.027	0.98	0.330	0.062	0.0042	1.00
	GERA Latino	0.294	0.232	0.0033	0.99	0.338	-0.099	0.84	1.00
	GERA East Asian	0.097	0.054	0.37	0.96	0.315	0.019	0.42	1.00
	GERA African American	0.202	-0.091	0.73	0.96	0.542	0.214	0.14	1.00
	GERA Meta-analysis of all	-	0.059	0.0060	-	-	0.048	0.015	-
Overall SDS	GERA Meta-analysis of all	-	0.053	0.0019	-	-	0.024	0.081	-