Table 3. Knee osteoarthritis prevalence in individuals with no cardiovascular related conventional medicine intake^a,b.

Factors	Subgroup	Total	Crude			Adjusted for age and sex			Fully adjusted
		n (case)	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
SBP (mmHg)c	≥148	493 (197)
	<148	409 (149)	1.00	0.71–1.41	0.985	1.12	0.77–1.63	0.5595	1.059	0.73–1.54	0.7616
	<140	1945 (620)	0.77	0.61–0.99	0.0404e	0.94	0.71–1.26	0.6874	0.939	0.71–1.25	0.6653
	<120	2209 (535)	0.56	0.44–0.72	< .0001e	0.77	0.58–1.03	0.0805	0.84	0.64–1.11	0.2172
DBP (mmHg)c	≥93	350 (90)
	<93	308 (101)	1.66	1.13–2.46	0.0106e	1.38	0.9–2.1	0.1379	1.393	0.9–2.16	0.139
	<90	1488 (426)	1.17	0.85–1.6	0.34	0.84	0.59–1.2	0.3369	0.848	0.59–1.23	0.3838
	<80	2910 (884)	1.45	1.08–1.95	0.0123e	0.79	0.56–1.11	0.1654	0.872	0.61–1.24	0.4437
Hypercholesterolemia (mg/dl)c	≥256	314 (105)
	<256	303 (96)	1.02	0.67–1.56	0.9119	0.92	0.59–1.46	0.7346	1.007	0.62–1.64	0.9759
	<240	2096 (587)	0.86	0.63–1.17	0.3388	0.86	0.61–1.22	0.4022	0.972	0.67–1.42	0.882
	<193	2012 (572)	0.87	0.63–1.2	0.3846	0.87	0.61–1.24	0.4397	1.053	0.71–1.56	0.796
Hypertriglyceridemia (mg/dl)c	≥251	333 (98)
	<251	331 (93)	1.11	0.74–1.67	0.6233	0.84	0.53–1.31	0.4312	0.926	0.59–1.46	0.742
	<200	1808 (544)	1.21	0.88–1.65	0.2394	0.84	0.59–1.19	0.3255	0.994	0.7–1.42	0.9752
	<103	1784 (543)	1.37	1.01–1.86	0.0465e	0.95	0.68–1.34	0.7743	1.288	0.91–1.82	0.1547
Hypoalphalipoproteinemia (mg/dl)c	<36	535 (161)
	<40	600 (181)	1.08	0.77–1.53	0.6534	1.11	0.76–1.61	0.5978	1.046	0.71–1.55	0.8223
	<50	1794 (549)	1.06	0.8–1.4	0.688	1.06	0.79–1.43	0.6933	1.155	0.84–1.59	0.38
	≥50	2004 (553)	0.95	0.72–1.25	0.7015	0.92	0.68–1.24	0.573	1.077	0.78–1.49	0.6504
Hyper-LDL cholesterolemia (mg/dl)c	≥148	245 (68)
	<148	239 (70)	0.96	0.6–1.54	0.8616	0.99	0.6–1.62	0.9652	1.003	0.6–1.68	0.9919
	<130	346 (76)	0.78	0.5–1.2	0.2607	0.84	0.53–1.35	0.4824	0.898	0.53–1.51	0.6868
	<106	337 (71)	0.70	0.45–1.08	0.1083	0.72	0.45–1.14	0.1614	0.885	0.53–1.48	0.641
Glucose (mg/dl)c	≥126	198 (64)
	<126	361 (114)	0.83	0.54–1.27	0.3814	0.83	0.51–1.36	0.4606	0.762	0.44–1.33	0.3376
	<110	4363 (1263)	0.80	0.56–1.15	0.2311	0.67	0.44–1.02	0.0599	0.717	0.45–1.15	0.1665
Smoking statusd	Current smokers	897 (185)
	Ex-smokers	1128 (271)	1.20	0.93–1.56	0.1676	0.96	0.72–1.28	0.7625	0.891	0.66–1.2	0.4433
	Nonsmokers	3039 (1044)	2.23	1.8–2.76	< .0001e	1.31	0.98–1.75	0.0671	1.197	0.88–1.62	0.2486

^a Knee osteoarthritis: K-L grade ≥2

^b Subjects without intake of medication for hyperlipemia, hypertension or diabetes

^c Adjusted for age, sex, education level, household income, occupation, BMI, present smoking status, alcohol consumption, regular exercise habits and mental health in fully adjusted model

^d Adjusted for age, sex, education level, household income, occupation, BMI, alcohol consumption, regular exercise habits and mental health in fully adjusted model

^e p < 0.05

OR: Odds ratio; CI: Confidence interval; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; LDL: Low density lipoprotein