Table 2. Immunologic, virologic and adherence patterns by baseline CD4+ cell count, previously ARV-naïve patients (N = 70,002).
Baseline CD4+ Cell Count, cells/mm3 | p-value | |||||
---|---|---|---|---|---|---|
Outcome/pattern evaluated | ≤100 | 101–200 | 201–350 | 351–500 | >500 | |
CD4+ cell count change by month 6, cells/mm3 (IQR) | 120 | 140 | 140 | <0.0001 | ||
(63–196) | (66–234) | (47–251) | ||||
% with viral suppression* by month 6 | 65.4 | 70.7 | 73.3 | 71.4 | 64.4 | <0.001 |
% with viral suppression* by month 12 | 72.3 | 77.0 | 79.3 | 78.4 | 73.1 | <0.001 |
% with average adherence ≥95% at month 6 | 63.1 | 62.9 | 64.2 | 56.5 | 52.5 | <0.001 |
% with average adherence <50% at month 6 | 6.4 | 6.5 | 6.3 | 11.7 | 14.3 | <0.001 |
*Viral suppression defined as VL≤400 cp/mL