Table 1. Detailed procedures of included trials.
| Trials | Treatment | Design | Follow-up (month) | Ablation Area | Target Identification | AADs Post- procedure | Primary Endpoint |
|---|---|---|---|---|---|---|---|
| GP Ablation Strategy | |||||||
| Scherlag 2005 3 | GP+PVI vs PVI | CCT | 1–15 | SLGP, ILGP, ARGP, IRGP | Selective | ___ | Freedom from AF |
| Pokushalov 2013 5 | GP+PVI vs PVI+LL | RCT | 36 | SLGP, ILGP, ARGP, IRGP, MGP | Selective | 3 months | Freedom from AF (AF burden≤0.5%) |
| Katritsis 2013 10 | GP+PVI vs PVI | RCT | 24 | SLGP, ILGP, ARGP, IRGP | Anatomic | 3 months | Freedom from AF or other sustained (duration>30s) atrial tachyarrhythmia |
| Katritsis 2011 11 | GP+PVI vs PVI | RCT | 11.3±1.9 | SLGP, ILGP, ARGP, IRGP | Anatomic | 2 months | Freedom from AF or other sustained (duration>30s) atrial tachyarrhythmia |
| CFAE Ablation Strategy | |||||||
| Verma 2015 7 | CFAE+PVI vs PVI | RCT | 18 | LA+RA+CS | Automated | 3 months | Freedom from AF or other sustained (duration>30s) atrial tachyarrhythmia |
| Vogler 2015 8 | CFAE+PVI vs PVI | RCT | 12 | LA+RA+CS | Automated | 3 months | No AF or other atrial arrhythmia on Holter monitor |
| Oral 2009 9 | CFAE+PVI vs PVI | RCT | 10±3 | LA+CS | Automated | 8–12 weeks | Freedom from AF or other sustained (duration>30s) atrial tachyarrhythmia 12 weeks after procedure |
| Verma 2008 12 | CFAE+PVI vs PVI | CCT | 12–18 | LA+CS | Automated | 2 months | No AF or other atrial arrhythmia on ECG/Holter monitor 3 months after procedure |
| Lin 2009 13 | CFAE+PVI+LL vs PVI+LL | CCT | 19±11 | LA+CS | Automated | 8 weeks | Freedom from AF or other sustained (duration>1min) atrial |
| Chen 2011 14 | CFAE+PVI vs PVI | RCT | 22.6±6.4 | LA+CS | Automated | No more | No AF or other sustained atrial arrhythmia (duration>1min) on ECG/Holter monitor 3 months after procedure without AADs |
| Baise 2009 15 | CFAE+PVI vs PVI | RCT | 13.7±2.2 | LA+RA+CS | Automated | 2 months | No episodes of AF/AT (duration>1min) 2 months after procedure with or without AADs |
| Elayi 2008 16 | CFAE+PVI vs PVI | RCT | 16±1 | LA+RA+CS | Automated | 2 months | Freedom from AF or other sustained (duration>1min) atrial tachyarrhythmia 2 months after procedure without AADs |
| Verma 2010 17 | CFA E+PVI vs PVI | RCT | 12 | LA+RA+CS | Automated | 2 months | Freedom from AF or other sustained (duration>30s) atrial tachyarrhythmia 3 months after procedure |
| Nam 2012 18 | CFAE+PVI vs PVI | CCT | 23±12 | LA+RA+CS | Automated | Reinitiated if symptomatic recurred | No episodes of AF/AFL on ECG/Holter monitor 3 months after procedure without AADs |
AF, atrial fibrillation; GP, ganglionated plexi; PVI, pulmonary vein isolation; RCT, randomized controlled trial; CCT, controlled clinical trial; SLGP, superior left GP; ILGP, inferior left GP; ARGP, anterior right GP; IRGP inferior right GP; MGP, Mashall tract GP; HFS, high frequency stimulation; AADs, anti-arrhythmia drugs.