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. 2016 Oct 20;12(10):e1005950. doi: 10.1371/journal.ppat.1005950

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© 2016 Ren et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 8 — BRD4 participates in epigenetics regulation by recognition of acetyl lysine residues with its bromodomains (BD1, BD2). BRD4 also regulates the transcription of cellular and viral genes by recruitment of the positive transcription elongation factor (P-TEFb) and transcriptional factors. P-TEFb is itself under a stringent control by the inhibitory 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. Infection by HSV-1 or HSV-2 causes BRD4 relocation and rededicates BRD4 and the protein complex to viral gene transcription. JQ1 (red dots) or BD1 domain proteins functions by dislodging BRD4 from chromatin association.