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. Author manuscript; available in PMC: 2016 Oct 20.
Published in final edited form as: Eur Cell Mater. 2016 Jul 19;32:123–136. doi: 10.22203/ecm.v032a08

Fig. 5.

Fig. 5

TRPV4 signalling mediates IVD cell expression of pro-inflammatory cytokines. Gene expression for the pro-inflammatory cytokines ( a) interleukin-1β and (b) interleukin-6 were increased after 24 h under hypo-osmotic conditions (334 mOsm/kgH2O). TRPV4 inhibition using the TRPV4 antagonist (GSK205) decreased the pro- inflammatory gene expression indicating that TRPV4 signalling was an important regulator of pro-inflammatory gene expression in the IVD. Bar = p < 0.05 and ǂ = p < 0.1.