Table 1.
Comparisons of Recordings of Organized and Disorganized Activity and of Organized Activity in Myocyte Cultures and Myocyte-Neuron Cocultures
| Organized versus Disorganized Activity | |||
|---|---|---|---|
| Feature | Org Median (IQ range) | Dis Median (IQ range) | p value |
| Number of cells | 4678 (4138–5087) | 4890 (4318–5573) | 0.1909 |
| Wavefront speed (mm/s)a | 11.3 (7.6–20.8) | 5.9 (5.2–7.4) | 0.0024 |
| Interspike period (ms) | 443.2 (331.8–564.3) | 372.1 (341.9–466.1) | 0.2673 |
| APD (ms) | 138.5 (112.1–180.4) | 138.2 (103.6–150.3) | 0.3286 |
| Cell sparseness (m) | 170.2 (152.8–204.6) | 192.4 (168.5–210.7) | 0.3453 |
| Wavefront roughness (°)a | 27.1 (23.3–30.9) | 37.7 (32.7–38.9) | 0.0010 |
| Beat frequency (Hz) | 0.838 (0.606–1.403) | 1.173 (0.894–1.437) | 0.1694 |
| Entropy | 0.322 (0.034–2.130) | 0.127 (0.060–0.509) | 0.7281 |
| Perimeter/area ratioa | 0.139 (0.093–0.162) | 0.188 (0.161–0.229) | 0.0022 |
| Organized Activity in Myocyte Cultures versus Myocyte-Neuron Cocultures | |||
| Feature | Myo Median (IQ range) | Co Median (IQ range) | p value |
| Number of cells | 4956 (4751–5313) | 4411 (4127–4835) | 0.1471 |
| Wavefront speed (mm/s)a | 6.5 (5.3–9.5) | 17.8 (11.1–21.5) | 0.0110 |
| Interspike period (ms)a | 564.3 (432.9–643.1) | 366.3 (307.7–464.6) | 0.0420 |
| APD (ms) | 180.4 (134.4–204.5) | 133.5 (107.3–151.3) | 0.0559 |
| Cell sparseness (m) | 184.3 (159.5–204.8) | 169.3 (146.1–204.4) | 0.7925 |
| Wavefront roughness (°) | 29.6 (24.1–38.6) | 26.6 (23.1–29.3) | 0.2635 |
| Beat frequency (Hz) | 0.599 (0.516–0.929) | 0.947 (0.815–1.891) | 0.0559 |
| Entropy | 0.667 (0.306–2.081) | 0.168 (0.003–2.179) | 0.3676 |
| Perimeter/area ratio | 0.152 (0.135–0.192) | 0.117 (0.084–0.162) | 0.2198 |
For each feature (or mean of feature), the median and interquartile range are given. Org, organized recordings (target, spiral, or straight wave); Dis, disorganized activity (wavelets); IQ, interquartile; Myo, cultures of myocytes; Co, cocultures of myocytes and neurons.
a
Features that differ significantly between the respective groups.