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. 2016 Oct 18;111(8):1714–1723. doi: 10.1016/j.bpj.2016.08.040

Table 2.

Apparent Partition Coefficients of CDC and GCDC at Different pH Values, Determined with the Laurdan (Indirect) Method

CDC (pKa = 5.0)
pH Lipid-Normalized Apparent Distribution Coefficient
Apparent Distribution Coefficient
DL [L·mol−1] logDL D logD
6.8∗∗ 912 ± 113 2.96 1170 ± 145 3.07
+0.05/−0.06 +0.05/−0.06
7.4∗∗ 547 ± 58 2.74 702 ± 74 2.85
+0.04/− 0.05 +0.04/−0.05
8.2∗∗
559 ± 96
2.75 716 ± 123
2.85
+0.07/− 0.08 +0.07/−0.08

GCDC (pKa = 3.9)

6.8 369 ± 59 2.57 472 ± 76 2.67 ± 0.07
+0.06/−0.08
7.4∗∗ 440 ± 43 2.64 ± 0.04 563 ± 55 2.75 ± 0.04
8.2 435 ± 210 2.64 557 ± 269 2.75
+0.17/−0.29 +0.17/−0.29

n = 2.

∗∗

n = 3.