Table 2.
Apparent Partition Coefficients of CDC and GCDC at Different pH Values, Determined with the Laurdan (Indirect) Method
| CDC (pKa = 5.0) | ||||
|---|---|---|---|---|
| pH | Lipid-Normalized Apparent Distribution Coefficient |
Apparent Distribution Coefficient |
||
| DL [L·mol−1] | logDL | D | logD | |
| 6.8∗∗ | 912 ± 113 | 2.96 | 1170 ± 145 | 3.07 |
| +0.05/−0.06 | +0.05/−0.06 | |||
| 7.4∗∗ | 547 ± 58 | 2.74 | 702 ± 74 | 2.85 |
| +0.04/− 0.05 | +0.04/−0.05 | |||
| 8.2∗∗ |
559 ± 96 |
2.75 | 716 ± 123 |
2.85 |
| +0.07/− 0.08 | +0.07/−0.08 | |||
| GCDC (pKa = 3.9) | ||||
| 6.8∗ | 369 ± 59 | 2.57 | 472 ± 76 | 2.67 ± 0.07 |
| +0.06/−0.08 | ||||
| 7.4∗∗ | 440 ± 43 | 2.64 ± 0.04 | 563 ± 55 | 2.75 ± 0.04 |
| 8.2∗ | 435 ± 210 | 2.64 | 557 ± 269 | 2.75 |
| +0.17/−0.29 | +0.17/−0.29 | |||
n = 2.
n = 3.