Table 2.
Baseline and Follow-Up Geriatric Assessment Scores of Older Adults Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia (N = 49)
| Assessment | Baseline | Follow-Up | Change | P-Value |
|---|---|---|---|---|
| Cognition: 3MS (range 0–100, impairment <80) | 84.7 ± 8.8 | 85.1 ± 9.4 | 0.4 ± 7.4 | .72 |
| Psychological function | ||||
| CES-D (range 0–60, impairment >16) | 13.9 ± 11.6 | 11.4 ± 10.7 | −2.5 ± 11.7 | .15 |
| Distress thermometer (range 0–10, impairment ≥4) | 5.0 ± 3.1 | 3.1 ± 3.1 | −1.9 ± 3.5 | <.001 |
| Physical function | ||||
| PAT-D (range 1–5, impairment>1) at the time of treatment | ||||
| Activity of daily living subscale | 1.3 ± 0.6 | 1.4 ± 0.5 | 0.2 ± 0.5 | .02 |
| Instrumental activity of daily living subscale | 1.4 ± 0.7 | 2.1 ± 1.0 | 0.8 ± 1.1 | <.001 |
| Mobility subscale | 2.1 ± 1.2 | 2.8 ± 1.4 | 0.7 ± 1.1 | <.001 |
| SPPB (range 0–12, impairment ≤9) | 7.6 ± 4.0 | 5.8 ± 4.3 | −1.8 ± 5.0 | .02 |
| Gait speed, m/s | 0.8 ± 0.2 | 0.9 ± 0.3 | 0.1 ± 0.2 | .19 |
| Balance score | 3.1 ± 1.5 | 2.5 ± 1.7 | −0.6 ± 1.9 | .03 |
| Gait speed score | 2.7 ± 1.6 | 1.9 ± 1.8 | −0.8 ± 2.1 | .01 |
| Chair stand score | 1.8 ± 1.4 | 1.4 ± 1.5 | −0.4 ± 1.8 | .12 |
| Grip strength, kg | ||||
| Male | 40.1 ± 7.2 | 34.8 ± 10.2 | −5.3 ± 4.6 | <.001 |
| Female | 24.6 ± 5.0 | 21.7 ± 4.8 | −2.9 ± 4.0 | .007 |
| ECOG | 1.1 ± 0.5 | 1.4 ± 0.65 | 0.3 ± 0.8 | .006 |
Sample size variability for specific reported outcomes based on available data is as follows: Modified Mini-Mental State Exam (3MS) (n = 46), Center for Epidemiologic Studies Depression Scale (CES-D) (n = 48), distress thermometer (n = 48), Pepper Assessment Tool for Disability (PAT-D) (n = 43), walking speed calculation for Short Physical Performance Battery (SPPB) (n = 38), grip strength (n = 40), Eastern Cooperative Oncology Group (ECOG) (n = 47). For 3MS, SPPB, and grip strength, higher scores reflect better function. For CES-D, distress thermometer, and PAT-D, higher scores reflect worse function.