Table 5.

Adverse events profiles in matched cohort.

	Any grade			Grade ≥ 3
	Dasatinib (N = 87)	Nilotinib (N = 87)	P value	Dasatinib (N = 87)	Nilotinib (N = 87)	P value
Hematological abnormality
Neutropenia	7(8)	8(9)	0.5	4(5)	3(3)	0.5
Anemia	32(37)	7(8)	<0.001	1(1)	0(0)	0.5
Thrombocytopenia	17(20)	5(6)	0.006	7(8)	4(5)	0.27
Biochemical abnormality
Elevated Bilirubin	3(3)	59(68)	<0.001	0(0)	7(8)	0.007
Elevated ALT	10(12)	47(54)	<0.001	0(0)	1(1)	0.5
Elevated AST	15(17)	38(44)	<0.001	0(0)	1(1)	0.5
Elevated ALP	1(1)	3(3)	0.31	0(0)	0(0)	NA
Hyperglycemia	1(1)	8(9)	0.017	0(0)	1(1)	0.5
Non-hematological AE
Fatigue	63(72)	38(44)	<0.001	11(13)	1(1)	0.002
Weight loss	2(2)	1(1)	0.5	0(0)	0(0)	NA
Anorexia	3(3)	3(3)	0.66	0(0)	0(0)	NA
Flu like	4(5)	1(1)	0.18	0(0)	0(0)	NA
Headache	42(48)	18(21)	<0.001	4(5)	0(0)	0.06
Mucositis	6(7)	2(2)	0.14	0(0)	0(0)	NA
Palpitations	8(9)	4(5)	0.19	0(0)	0(0)	NA
Prolonged QTc	1(1)	2(2)	0.5	1(1)	0(0)	0.5
Cough	17(20)	1(1)	<0.001	0(0)	0(0)	NA
Dyspnea	49(56)	5(6)	<0.001	8(9)	0(0)	0.003
Nausea	42(48)	20(23)	<0.001	1(1)	1(1)	0.751
Vomiting	24(28)	6(7)	<0.001	0(0)	0(0)	NA
Diarrhea	51(59)	8(9)	<0.001	4(5)	0(0)	0.06
Constipation	28(32)	8(9)	<0.001	0(0)	0(0)	NA
Pruritus	8(9)	22(25)	0.005	0(0)	0(0)	NA
Acne	12(14)	2(2)	0.005	0(0)	0(0)	NA
Erythema Multiforme	4(5)	1(1)	0.18	0(0)	0(0)	NA
Dizziness	38(44)	4(5)	<0.001	2(2)	0(0)	0.25
Sensory neuropathy	37(43)	2(2)	<0.001	3(3)	0(0)	0.12
Memory impairment	39(45)	2(2)	<0.001	5(6)	0(0)	0.029
Edema	37(43)	1(1)	<0.001	0(0)	0(0)	NA
Myalgia	39(45)	8(9)	<0.001	7(8)	0(0)	0.007
Pleural effusion	18(21)	0(0)	<0.001	0(0)	0(0)	NA
Cardiovascular event	0(0)	2(2)	0.25	0(0)	1(1)	0.5