Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesth Analg. 2016 Nov;123(5):1263–1273. doi: 10.1213/ANE.0000000000001368

Figure 2. The importance of potency in governing selective binding to general anesthetic sites.

Figure 2

The correlation between EC50 for loss of righting reflexes (LoRR) in tadpoles and octanol/water partition coefficient holds well for anesthetics with EC50s above ~50 µM (Pearson correlation coefficient = −0.987; P < 0.0001). More potent agents display weak dependence on partition coefficient (Pearson correlation coefficient = −0.209; P = 0.49; yellow box). Some of the most successful photolabels lie in this group and are more potent than predicted by hydrophobicity (points with light blue fill). Data sources are given in (46).