Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesth Analg. 2016 Nov;123(5):1263–1273. doi: 10.1213/ANE.0000000000001368

Figure 3. Selectivity of general anesthetic binding to crystallized homomeric cation–conducting pLGICs is dependent on potency.

Figure 3

A. Bromoform (brown), a low potency drug, occupies eleven sites in three different classes on ELIC (33): (1) 5 homologous intrasubunit sites in the extracellular domain (ECD); (2) 5 homologous sites in the lipid-protein interface of the transmembrane domain, and (3) a single site in the channel lumen at the interface of all five subunits. B. Ketamine (carbons grey, nitrogen blue, chlorine green) occupies a single class of 5 intersubunit sites on GLIC (34), which potently and stereoselectively inhibits. Channel subunits are shown as ribbons and are colored arbitrarily. The anesthetics are shown space filled and colored conventionally.