Figure 4. Selectivity of general anesthetics for intersubunit sites in α1β3γ2L GABA_ARs.

The homology model and coloring are as in Figure 1, and the view of the transmembrane domain () is from the synaptic side with the extracellular domain removed. Subunit interfaces are labeled (note that “+” corresponds to M3 helices and “−” corresponds to M1 helices). Photolabels that selectively bind in each interface are identified in colored boxes, and white boxes identify the general anesthetics that compete with photolabels for occupancy of that interface.