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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Anesth Analg. 2016 Nov;123(5):1263–1273. doi: 10.1213/ANE.0000000000001368

Figure 6. Combining photolabel and SCAMP results to map the β+ – α− interfacial anesthetic sites.

Figure 6

The homology model is based on the GluCl chloride channel (3RHW.pdb) (7,26). The five subunits are colored as follows: α1, yellow; β3, red, and γ2 green. The transmembrane helical backbones are depicted as ribbons. Residues in this site identified with either photolabeling or SCAMP are shown as space-filling atomic models and labeled. Contact residues are coded by coloring their carbons. Residues photolabeled by etomidate and propofol derivatives show cyan and pink carbons, respectively. Grey carbons indicate binding site residues identified by SCAMP with either etomidate or propofol. Red and blue atoms are oxygen and nitrogen respectively. Also shown in ball and stick mode are three residues in the γ+ – β− inter-subunit region that are discussed in the text: γ2S301, β3M227, and β3H267.