Figure 10.

Comparison of the estimated on-rate coefficient, $k_{\text{on},\text{funnel}}$ (blue lines), with the measured one (magenta) as a function of the target volume position, x, for multiple lower thresholds, $x_{\text{bound}}$. For $0.6\text{nm}<x<0.8\text{nm}$, the estimated on-rate coefficient is almost independent of x, justifying the assumption of the funnel model. Within the range of considered values of $x_{\text{bound}}$, the on-rate estimate varies only by a factor of 3. To see this figure in color, go online.