Fig. 6.

In vivo biodistribution of radiolabelled EL, L-ALD and L-ZOL in A375Pβ6 tumour bearing NSG mice after single dose administration via tail vein injection. NSG mice were inoculated bifocally with the A375Pβ6 cell line and were i.v. injected with ¹¹¹In labelled liposomes at a dose of 2 μmol lipid/mouse. (A) Blood clearance profile of liposomes expressed as %ID. (B) Results were expressed as percentage injected dose per gram of organ (%ID/g organ) at 24 h after injection of 2 μmol liposome/mouse. L-ZOL and L-ALD was seen to have higher spleen accumulation than EL. Data are expressed as mean ± SD (n = 3) *p < 0.05, **p < 0.01. (Student's t-test vs. naive).