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. 2016 Nov 10;241:229–241. doi: 10.1016/j.jconrel.2016.09.023

Table 1.

Haematological resultsa from male non-tumour bearing NSG mice treated with a single dose of 0.1 μmol L-ZOL or 0.5 μmol L-ALD and sampled 72 h after dosingb.

Controlc
L-ZOLc
L-ALDc
Mean ± SD Range Mean ± SD Range Mean ± SD Range
WBC 0.8 ± 0.2 0.6–1.0 3.2 ± 2.5⁎⁎ 1.3–3.2 2.2 ± 0.5⁎⁎⁎ 1.7–2.8
Neutrophils 0.5 ± 0.1 0.4–0.7 3.0 ± 2.5⁎⁎ 1.3–2.8 2.0 ± 0.5⁎⁎⁎ 1.5–2.6
Neutrophils % 66.2 ± 7.9 66.0–76.0 92.2 ± 4.3⁎⁎⁎ 87.0–97.0 88.6 ± 3.7⁎⁎⁎ 83.0–91.0
Lymphocytes 0.2 ± 0.1 0.1–0.2 0.1 ± 0.1 0.0–0.2 0.1 ± 0.1 0.0–0.2
Lymphocytes % 21.0 ± 10.4 10.0–22.0 3.0 ± 1.7⁎⁎ 2.0–6.0 5.2 ± 2.2 2.0–8.0
Monocytes 0.1 ± 0.1 0.0–0.2 0.1 ± 0.1 0.0–0.1 0.1 ± 0.1 0.1–0.2
Monocytes % 10.6 ± 7.9 3.0–23.0 3.8 ± 3.0 1.0–8.0 6.0 ± 3.4 3.0–11.0
Eosinophils 0.0 ± 0.0 0.0–0.0 0.0 ± 0.0 0.0–0.0 0.0 ± 0.0 0.0–0.0
Eosinophils % 2.2 ± 1.3 0.0–3.0 1.0 ± 1.2 0.0–3.0 0.2 ± 0.4 0.0–1.0
Basophils 0.0 ± 0.1 0.0–0.1 0.0 ± 0.0 0.0–0.0 0.0 ± 0.0 0.0–0.0
Basophils % 3.7 ± 5.1 0.0–9.8 0.0 ± 000 0 0.0–0.0 0.0 ± 0.0 0.0–0.0
RBC 7.7 ± 0.6 7.1–8.7 8.0 ± 0.4 7.4–8.4 7.9 ± 0.5 7.3–8.4
HGB 13.0 ± 1.2 12.1–14.8 13.5 ± 0.7 12.6–14.3 12.7 ± 0.6 12.0–13.3
HCT 43.0 ± 4.3 38.2–49.1 44.2 ± 1.6 42.2–45.6 42.0 ± 2.4 38.8–44.3
MCV 56.1 ± 1.9 53.4–58.7 55.3 ± 1.5 53.6–57.6 52.9 ± 0.5⁎⁎ 52.6–53.7
MCH 17.0 ± 0.4 16.2–17.3 16.9 ± 0.4 16.4–17.5 16.0 ± 0.3⁎⁎ 15.7–16.3
MCHC 30.2 ± 1.0 29.4–31.7 30.5 ± 0.8 29.4–31.4 30.3 ± 0.4 29.9–30.8
RDW 14.6 ± 0.6 13.7–15.2 14.7 ± 0.4 14.0–15.0 14.6 ± 0.2 14.3–14.7
PLT 1331.0 ± 104.2 1179–144 1223.4 ± 194.2 1023–1501 1472. ± 145.7 1232–1572
PCV 35.4 ± 5.2 34.0–44.0 36.0 ± 2.7 32.0–39.0 35.4 ± 2.1 34.0–39.0

Student's t-test vs. naive.

a

Values are means ± SD (n = 5).

b

Abbreviations and units: WBC, white blood cell, 10e9/L; Neutrophils, 10e9/L; Lymphocytes, 10e9/L; Monocytes, 10e9/L; Eosinophils, 10e9/L; Basophils, 10e9/L; RBC, red blood cells, 10e12/L; HGB, haemoglobin, g/dL; HCT, haematocrit, %; MCV, mean cell volume, fL; MCH, mean cell haemoglobin, pg; MCHC, mean cell haemoglobin concentration, g/dL; RDW, rec cell distribution width, %; PLT, platelets, 10e9/L; PCV, packed cell volume, %.

c

Data was expressed as means ± SD (n = 5).

p < 0.05.

⁎⁎

p < 0.01.

⁎⁎⁎

p < 0.001.