Table 1.
Haematological resultsa from male non-tumour bearing NSG mice treated with a single dose of 0.1 μmol L-ZOL or 0.5 μmol L-ALD and sampled 72 h after dosingb.
| Controlc |
L-ZOLc |
L-ALDc |
||||
|---|---|---|---|---|---|---|
| Mean ± SD | Range | Mean ± SD | Range | Mean ± SD | Range | |
| WBC | 0.8 ± 0.2 | 0.6–1.0 | 3.2 ± 2.5⁎⁎ | 1.3–3.2 | 2.2 ± 0.5⁎⁎⁎ | 1.7–2.8 |
| Neutrophils | 0.5 ± 0.1 | 0.4–0.7 | 3.0 ± 2.5⁎⁎ | 1.3–2.8 | 2.0 ± 0.5⁎⁎⁎ | 1.5–2.6 |
| Neutrophils % | 66.2 ± 7.9 | 66.0–76.0 | 92.2 ± 4.3⁎⁎⁎ | 87.0–97.0 | 88.6 ± 3.7⁎⁎⁎ | 83.0–91.0 |
| Lymphocytes | 0.2 ± 0.1 | 0.1–0.2 | 0.1 ± 0.1 | 0.0–0.2 | 0.1 ± 0.1 | 0.0–0.2 |
| Lymphocytes % | 21.0 ± 10.4 | 10.0–22.0 | 3.0 ± 1.7⁎⁎ | 2.0–6.0 | 5.2 ± 2.2⁎ | 2.0–8.0 |
| Monocytes | 0.1 ± 0.1 | 0.0–0.2 | 0.1 ± 0.1 | 0.0–0.1 | 0.1 ± 0.1 | 0.1–0.2 |
| Monocytes % | 10.6 ± 7.9 | 3.0–23.0 | 3.8 ± 3.0 | 1.0–8.0 | 6.0 ± 3.4 | 3.0–11.0 |
| Eosinophils | 0.0 ± 0.0 | 0.0–0.0 | 0.0 ± 0.0 | 0.0–0.0 | 0.0 ± 0.0 | 0.0–0.0 |
| Eosinophils % | 2.2 ± 1.3 | 0.0–3.0 | 1.0 ± 1.2 | 0.0–3.0 | 0.2 ± 0.4⁎ | 0.0–1.0 |
| Basophils | 0.0 ± 0.1 | 0.0–0.1 | 0.0 ± 0.0 | 0.0–0.0 | 0.0 ± 0.0 | 0.0–0.0 |
| Basophils % | 3.7 ± 5.1 | 0.0–9.8 | 0.0 ± 000 | 0 0.0–0.0 | 0.0 ± 0.0 | 0.0–0.0 |
| RBC | 7.7 ± 0.6 | 7.1–8.7 | 8.0 ± 0.4 | 7.4–8.4 | 7.9 ± 0.5 | 7.3–8.4 |
| HGB | 13.0 ± 1.2 | 12.1–14.8 | 13.5 ± 0.7 | 12.6–14.3 | 12.7 ± 0.6 | 12.0–13.3 |
| HCT | 43.0 ± 4.3 | 38.2–49.1 | 44.2 ± 1.6 | 42.2–45.6 | 42.0 ± 2.4 | 38.8–44.3 |
| MCV | 56.1 ± 1.9 | 53.4–58.7 | 55.3 ± 1.5 | 53.6–57.6 | 52.9 ± 0.5⁎⁎ | 52.6–53.7 |
| MCH | 17.0 ± 0.4 | 16.2–17.3 | 16.9 ± 0.4 | 16.4–17.5 | 16.0 ± 0.3⁎⁎ | 15.7–16.3 |
| MCHC | 30.2 ± 1.0 | 29.4–31.7 | 30.5 ± 0.8 | 29.4–31.4 | 30.3 ± 0.4 | 29.9–30.8 |
| RDW | 14.6 ± 0.6 | 13.7–15.2 | 14.7 ± 0.4 | 14.0–15.0 | 14.6 ± 0.2 | 14.3–14.7 |
| PLT | 1331.0 ± 104.2 | 1179–144 | 1223.4 ± 194.2 | 1023–1501 | 1472. ± 145.7 | 1232–1572 |
| PCV | 35.4 ± 5.2 | 34.0–44.0 | 36.0 ± 2.7 | 32.0–39.0 | 35.4 ± 2.1 | 34.0–39.0 |
Student's t-test vs. naive.
a
Values are means ± SD (n = 5).
b
Abbreviations and units: WBC, white blood cell, 10e9/L; Neutrophils, 10e9/L; Lymphocytes, 10e9/L; Monocytes, 10e9/L; Eosinophils, 10e9/L; Basophils, 10e9/L; RBC, red blood cells, 10e12/L; HGB, haemoglobin, g/dL; HCT, haematocrit, %; MCV, mean cell volume, fL; MCH, mean cell haemoglobin, pg; MCHC, mean cell haemoglobin concentration, g/dL; RDW, rec cell distribution width, %; PLT, platelets, 10e9/L; PCV, packed cell volume, %.
c
Data was expressed as means ± SD (n = 5).
⁎
p < 0.05.
⁎⁎
p < 0.01.
⁎⁎⁎
p < 0.001.