Figure S6.

Representative images of the different scoring categories for glomerular injury showing a normal glomerulus, score 0 (A); a glomerulus with increased mesangial matrix deposition and some loss of capillary loops, score 1 (B); a glomerulus with increased mesangial matrix deposition and focal areas of sclerosis, score 2 (C); a glomerulus with >50% sclerotic area and very few capillary loops, score 3 (D); and a sclerotic glomerulus with an epithelial hyperplastic lesion (*) and a bridge formed between the glomerular tuft and the Bowman capsule indicated by an arrow, score 4 (E). Bar = 20 μm. (F) Proportions of glomeruli in the different scoring categories of glomerular injury in Tmsb4x^+/y (n = 5), Tmsb4x^+/y + NTS (n = 9), and Tmsb4x^−/y + NTS (n = 6) mice. Bars represent the mean ± SEM.