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. 2016 Nov;90(5):1056–1070. doi: 10.1016/j.kint.2016.06.032

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© 2016 International Society of Nephrology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Assessment of fibrosis in nephrotoxic nephritis. Representative images showing collagen IV staining in glomeruli of Tmsb4x^+/y (a), Tmsb4x^+/y + nephrotoxic serum (NTS) (b), and Tmsb4x^−/y + NTS (c) mice. (d) Quantification of collagen IV (Col4a1) mRNA levels in whole-kidney homogenates of Tmsb4x^+/y (n = 8), Tmsb4x^+/y + NTS (n = 9), and Tmsb4x^−/y + NTS (n = 6) mice. Representative images showing α-smooth muscle actin (α-SMA) staining in glomeruli of Tmsb4x^+/y (e) Tmsb4x^+/y + NTS (f) and Tmsb4x^−/y + NTS (g) mice. (h) Quantification of α-SMA (Acta2) mRNA levels in whole-kidney homogenates of Tmsb4x^+/y (n = 8), Tmsb4x^+/y + NTS (n = 8), and Tmsb4x^−/y + NTS (n = 5) mice. Data are presented as mean ± SEM. *P ≤ 0.05, **P ≤ 0.01. Bar = 20 μm. Tmsb4x, thymosin β₄.