Table 2.

Comparison of KPC-2 plasmid and plasmid from corresponding carbapenem-susceptible strain and of minimal inhibitory concentration of transformants.

Transformantsa	KP1-S	KP1-R	KP2-S	KP2-R	MM-S	MM-R	EA-R
Plasmid	pKP1-S	pKP1-R	pKP2-S	pKP2-R	pMM-S	pMM-R	pEA-R
Plasmid size (approximately kb)	≈140	≈140	≈170	≈170	≈170	≈150	≈40
Inc group	IncFIIk	IncFIIk	IncFII; IncR	IncFII; IncR	IncA/C2	IncFII; IncN	Non-typable
β-lactamase genes in plasmid	TEM-1;	KPC-2 TEM-1;	TEM-1;	KPC-2 TEM-1;	TEM-1;	KPC-2	KPC-2
	CTX-M-9	CTX-M-9;	SHV-11;	SHV-11;	CTX-M-9
Minimum inhibitory concentrations (μg/ml)
Imipenem	≤0.06	0.125	≤0.06	0.25	≤0.06	1	0.5
Ertapenem	≤0.06	0.25	≤0.06	0.25	≤0.06	2	0.5
Piperacillin/tazobactam	4	64	2	64	4	>128	>128
Ceftazidime	2	4	32	32	1	32	>128
Amikacin	1	1	>128	>128	4	2	1
Levofloxacin	≤0.06	≤0.06	≤0.06	≤0.06	≤0.06	≤0.06	≤0.06

^aKP, Klebsiella pneumoniae; MM, Morganella morganii; EA, Enterobacter aerogenes.