Figure 1.

Outer surface protein regulation. B. burgdorferi senses changes in temperature, pH, and cell density, as well as unknown stimuli to modulate production of proteins on the bacterial surface. Proteins listed are upregulated in their respective environments, in the tick vector or the mammalian host, or are produced at similar levels in both environments. Proteins produced during mammalian infection are grouped based on temporal expression pattern, expressed early during infection (early), during persistent infection (late), or those that have been detected both early and late during infection or have not been experimentally determined (both/untested). ^aBased on in vivo qRT-PCR and microarray data (15). ^(#)Reference. Underline indicates genes regulated by the RpoS regulon.