. Author manuscript; available in PMC: 2016 Oct 21.

Published in final edited form as: Exp Cell Res. 2007 Apr 6;313(10):2180–2188. doi: 10.1016/j.yexcr.2007.04.005

Table 1.

Summary of the phenotypes of BFSP1 (filensin) and BFSP2 (CP49) knockouts

Knockouts	BFSP1 (filensin)	BFSP2 (CP49)
Lens phenotypes	No obvious change in lens morphology. Normal lens development and fibre cell differentiation	No obvious change in lens morphology. Substantial change in fibre cell membrane architecture
Optical property	Light scatter starts at 2 months, worsened with age	Loss of optical function that worsened with age
Cataract	No	No
Levels of assembly partner	Reduced	Reduced
Beaded filament	Lost	Lost, but vimentin filaments now have modified morphology
Heterozygous mice	Exhibited intermediate phenotype	Similar to WT litter mates