Table 3.

Tiotropium Respimat^® Pharmacokinetic Parameters at Steady State

	Tiotropium Respimat®5 μg QD			Tiotropium Respimat®2.5 μg BID
Parameter	n	Geometric mean	Geometric CV (%)	n	Geometric mean	Geometric CV (%)
AUC(0–24h)ss, pg·h/mL	24	43.8	28.9	23	45.3	20.6
AUC(0–12h)ss, pg·h/mL	31	23.4	33.5	26	21.5	25.3
Cmax,ss, pg/mL	34	4.95	106	33	3.10	40.4
Cmax,ss,2, pg/mL	–	–	–	34	3.23	50.8
Ae(0–24h)ss, ng	32	677	54.2	34	722	49.4

Pharmacokinetic subset (n = 35).

Ae_(0–24h)ss, urinary excretion over 24 hours at steady state; AUC_(0–12h)ss, area under the curve from 0 to 12 hours at steady state; AUC_(0–24h)ss, area under the curve over 24 hours at steady state; BID, twice daily; C_max,ss, steady-state maximum plasma concentration after the evening dose; C_max,ss,2, steady-state maximum plasma concentration after the morning dose; CV, coefficient of variation; QD, once daily.