Table 1. Univariate analysis for survival outcomes by clinicopathological features.
| Variables | No. of cases | Overall survival |
Disease free survival |
||||
|---|---|---|---|---|---|---|---|
| No. of deaths (%)a | 5Y-OSR (%)b | Log-rank P | No. of events (%)a | 5Y-DFSR (%)b | Log-rank P | ||
| Overall | 782 | 208 (26.6) | 62 | 340 (43.5) | 45 | ||
| Age (years) | |||||||
| < 65 | 383 | 88 (23.0) | 69 | 2 × 10−3 | 162 (42.3) | 48 | 0.14 |
| ≥ 65 | 399 | 120 (30.1) | 55 | 178 (44.6) | 41 | ||
| Sex | |||||||
| Male | 572 | 173 (30.2) | 59 | 4 × 10−4 | 261 (45.6) | 42 | 0.10 |
| Female | 210 | 35 (16.7) | 71 | 79 (37.6) | 52 | ||
| Smoking status | |||||||
| Never | 232 | 40 (17.2) | 74 | 3 × 10−4 | 90 (38.8) | 50 | 0.15 |
| Ever | 550 | 168 (30.6) | 57 | 250 (45.5) | 43 | ||
| Diabetes | |||||||
| No | 619 | 150 (24.2) | 66 | 0.03 | 259 (41.8) | 47 | 0.19 |
| Yes | 152 | 51 (33.6) | 51 | 73 (48.0) | 36 | ||
| Histological types | |||||||
| SCC | 341 | 103 (30.2) | 60 | 0.17 | 146 (42.8) | 48 | 0.22 |
| AC | 425 | 99 (23.3) | 63 | 184 (43.3) | 42 | ||
| LCC | 16 | 6 (37.5) | 59 | 10 (62.5) | 35 | ||
| Pathologic stage | |||||||
| I | 378 | 59 (15.6) | 76 | 1 × 10−11 | 107 (28.3) | 60 | 2 × 10−15 |
| II | 227 | 81 (35.7) | 52 | 116 (51.1) | 39 | ||
| IIIA | 177 | 68 (38.4) | 47 | 117 (66.1) | 20 | ||
| Adjuvant therapyc | |||||||
| No | 184 | 72 (39.6) | 49 | 0.58 | 102 (56.0) | 37 | 0.36 |
| Yes | 220 | 77 (34.7) | 50 | 131 (59.0) | 25 | ||
| Body mass index | |||||||
| < 25 | 464 | 107 (23.1) | 65 | 200 (43.1) | 41 | ||
| ≥ 25 | 183 | 45 (24.6) | 61 | 0.85 | 75 (41.0) | 46 | 0.40 |
Abbreviations: 5Y-OSR, five year-overall survival rate; 5Y-DFSR, five year-disease free survival rate; SCC, squamous cell carcinoma; AC, adenocarcinoma; LCC, large cell carcinoma.
aRow percentage.
bFive year-overall survival rate and five year-disease free survival rate, proportion of survival derived from Kaplan-Meier analysis.
cIn pathologic stages II + IIIA: 182 cases received adjuvant chemotherapy alone, 11 cases received adjuvant radiotherapy alone, and 27 cases received both chemotherapy and radiotherapy.