Table 4. Combined effects of the SNPs on overall survival and disease free survival.
| No. of bad genotypesa | No. of cases (%)b | Overall survival |
Disease free survival |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of deaths (%)c | 5Y-OSR (%)d | P (L-R) | HR (95% CI)e | Pe | No. of events (%)c | 5Y-DFSR (%)d | P (L-R) | HR (95% CI)e | Pe | ||
| All casesf | |||||||||||
| 0 or 1g | 145 (19.5)f | 20 (13.8) | 79 | 5 × 10−4 | 1.00 | 38 (26.2) | 63 | 6 × 10−7 | 1.00 | ||
| 2 | 279 (37.6) | 78 (28.0) | 60 | 2.26 (1.36–3.74) | 2 × 10−3 | 126 (45.2) | 44 | 2.02 (1.40–2.93) | 2 × 10−4 | ||
| 3 | 231 (31.1) | 68 (29.4) | 58 | 2.59 (1.55–4.32) | 3 × 10−4 | 107 (46.3) | 40 | 2.35 (1.62–3.43) | 8 × 10−6 | ||
| 4 | 88 (11.8) | 27 (30.7) | 53 | 2.62 (1.46–4.70) | 1 × 10−3 | 45 (51.1) | 38 | 2.37 (1.54–3.67) | 1 × 10−4 | ||
| Ptrend | 8 × 10−4 | 3 × 10−5 | |||||||||
| 0 + 1g | 145 (19.5)f | 20 (13.8) | 79 | 3 × 10−5 | 1.00 | 38 (26.2) | 63 | 9 × 10−7 | 1.00 | ||
| 2 + 3 + 4 | 598 (80.5) | 173 (29.0) | 58 | 2.44 (1.51–3.92) | 3 × 10−4 | 278 (46.5) | 41 | 2.20 (1.56–3.10) | 8 × 10−6 | ||
| SCCh | |||||||||||
| 0 | 41 (12.4) | 4 (9.8) | 86 | 2 × 10−3 | 1.00 | 7 (17.1) | 74 | 3 × 10−6 | 1.00 | ||
| 1 | 120 (36.3) | 31 (25.8) | 66 | 3.28 (0.99–10.87) | 0.05 | 45 (37.5) | 54 | 3.04 (1.28–7.21) | 0.01 | ||
| 2 | 116 (35.1) | 40 (34.5) | 52 | 5.30 (1.62–17.37) | 6 × 10−3 | 56 (48.3) | 38 | 4.56 (1.94–10.73) | 5 × 10−4 | ||
| 3 | 54 (16.3) | 24 (44.4) | 46 | 7.67 (2.28–25.80) | 1 × 10−3 | 32 (59.3) | 37 | 6.76 (2.77–16.50) | 3 × 10−5 | ||
| Ptrend | 2 × 10−5 | 5 × 10−7 | |||||||||
Abbreviations: 5Y-OSR, five year-overall survival rate; 5Y-DFSR, five year-disease free survival rate; HR, hazard ratio; CI, confidence interval; PL-R, Log-rank P; SCC, squamous cell carcinoma; AC, adenocarcinoma.
aENO1 rs2274971 AA, PFKM rs11168417 CT + TT, PFKP rs1132173 CC + CT, and PDK2 rs3785921 GA + AA.
bColumn percentage.
cRow percentage.
dFive year-overall survival rate and five year-disease free survival rate, proportion of survival derived from Kaplan-Meier analysis.
eHRs, 95% CIs, and their corresponding P values were calculated using multivariate Cox proportional hazard models, adjusted for age, gender, smoking status, diabetes, tumor histology, pathologic stage, adjuvant therapy, and body mass index.
fCombined genotypes of rs11168417, rs2274971, rs3785921, rs1132173. Thirty nine patients with missing genotype data at any of the four SNPs.
g21 cases for zero bad genotype and 124 cases for one bad genotype. Because zero bad genotype had no death, zero and one bad genotypes were combined.
hCombined genotypes of rs11168417, rs2274971, rs3785921. Ten patients with missing genotype data at any of the three SNPs.