Figure 6.

Chronic METH treatment enhances baseline dopamine release in the ventral pallidum. Mice were sensitized to METH or saline (2 mg/kg, IP, 7 days). METH pretreated animals have enhanced baseline DA release. In RVP slices, METH pretreatment augmented baseline dopamine release by 508% (A,C, p = 0.003, n = 6, two-tailed t test). In CVP slices, METH pretreatment increased dopamine release by 307% (B,D, p = 0.017, n = 8, two-tailed t test). RVP release is correlated with motor behavior (E, r² = 0.6449, p = 0.0296, n = 7, linear regression analysis), whereas there is no correlation between baseline dopamine release and motor behavior in the CVP (F, r² = 0.001, p = 0.931, n = 8, linear regression analysis).