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. 2016 Oct 21;7:1680. doi: 10.3389/fmicb.2016.01680

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Copyright © 2016 Ruppen, Lupo, Decosterd and Sendi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-kill assays with penicillin 0.048 mg/L. Results are displayed as mean ± standard error of the mean (SEM). PEN 0.048 mg/L monotherapy (●), PEN 0.048 mg/L plus GEN 4 mg/L () and PEN 0.048 mg/L plus GEN 12.5 mg/L (). Isolates: GBS-PJI, periprosthetic joint infection (A); GBS-IE, infective endocarditis (B); NEM316, neonatal sepsis (C); GBS-Col, colonization isolate (D); GBS-HLGR, high-level gentamicin resistance (E). Growth controls of all isolates (F). LOQ: lower limit of quantification.

Inline graphic — Time-kill assays with penicillin 0.048 mg/L. Results are displayed as mean ± standard error of the mean (SEM). PEN 0.048 mg/L monotherapy (●), PEN 0.048 mg/L plus GEN 4 mg/L () and PEN 0.048 mg/L plus GEN 12.5 mg/L (). Isolates: GBS-PJI, periprosthetic joint infection (A); GBS-IE, infective endocarditis (B); NEM316, neonatal sepsis (C); GBS-Col, colonization isolate (D); GBS-HLGR, high-level gentamicin resistance (E). Growth controls of all isolates (F). LOQ: lower limit of quantification.