Table 2.

Association of academic performance across HS grades with leptin status at 16–17 years (n=568)

	Hyperleptinaemia (n=83)	Normal leptin levels (n=485)	Mean score difference
HS grade level	Mean score	Mean score		(95% CI)	t	p Value
9th	437.6	476.2	−38.6	−63.6 to −13.6	−3.04	0.002
10th	446.7	478.1	−31.4	−157.5 to −5.32	−2.36	0.018
11th	456.3	484.4	−28.1	−54.6 to −1.52	−2.08	0.038
12th	470.3	500.1	−29.8	−57.2 to −2.48	−2.14	0.033
Final GPA	454.9	488.7	−33.8	−56.9 to −10.7	−2.88	0.004

Grades (9th to 12th) and final GPA expressed as scores, according to the Chilean Ministry of Education.

Hyperleptinaemia defined according to the cut-offs published by Köster-Weber et al.

Adjustments were made for weight status and insulin sensitivity at 16–17 years.

GPA, grade point average; HS, high school.