Table 3.

Genetic etiologies in human epilepsies with both mild and severe phenotypes

Gene	Mild phenotype	Severe phenotype
SCN1A	genetic epilepsy with febrile seizures plus	Dravet syndrome
SCN2A	benign familial neonatal-infantile seizures	neonatal epileptic encephalopathy
SCN8A	benign familial neonatal-infantile seizures	early-onset epileptic encephalopathy
KCNQ2	benign familial neonatal seizures	neonatal epileptic encephalopathy
SLC2A1	familial focal epilepsy	neonatal epileptic encephalopathy (De Vivo syndrome)
GABRA1	juvenile myoclonic epilepsy	early-onset epileptic encephalopathy
GABRG2	genetic epilepsy with febrile seizures plus	early-onset epileptic encephalopathy
GRIN2A	epilepsy-aphasia syndromes	early-onset epileptic encephalopathy
PRRT2	benign familial infantile seizures	early-onset epileptic encephalopathy