Table 5.
Modular PKS and NRPS gene clusters in Streptomyces sp. MWW064
| Gene cluster | Encoded in | No. of modular PKS and NRPS genes | No. of modules | Backbone of predicted product |
|---|---|---|---|---|
| pks/nrps-1 (rak) | scaffold 9 | 6 | 7 | R-C3-C3-Ser-C2-Gly-X |
| pks/nrps-2 | scaffold 5 | 6 | 14 | C2-C2-C2-C2-C2-Gly-C2-C2-C2-C2-C2-C2-C2-C2 |
| pks/nrps-3 | scaffold 2 | 4 | 3 | C?-C?-X |
| pks/nrps-4 | scaffold 11 | 1 | 2 | X-C2 |
| pks-1 | scaffold 18 | 5 | 5 | C?-C3-C2-C2-C? |
| pks-2 | scaffold 23 | 1 | 1 | C? |
| other pks a | scaffolds 11, 39, 45 | >3 | >10 | C2-C2-C3-C2, C2-C2, C2-C2-C2, C2 |
| nrps-1 | scaffold 11 | 4 | 4 | X-X-Val-X |
| nrps-2 | scaffold 18 | 3 | 3 | R-Val-X |
| nrps-3 | scaffold 9 | 2 | 3 | R-Cys-mCys |
| nrps-4 | scaffold 13 | 3 | 4 | Val-Gly-Ser-Pro |
| nrps-5 | scaffold 2 | 1 | 1 | Ser |
| nrps-6 | scaffold 12 | 1 | 1 | Thr |
| other nrps a | scaffolds 3, 5 | >2 | >6 | X-X-X-X-X, Cys |
anot completely sequenced. R, starter unit; C3, C3 unit derived from methylmalonyl-CoA; C2, C2 unit derived from malonyl-CoA; X, unpredictable amino acid; C?, unpredictable carbon unit derived from acyl-CoA; mCys, methylated cysteine