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. 2016 Oct 21;10:97. doi: 10.1186/s12918-016-0343-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Exaptation potential and non-essential reactions. Vertical axes show (a) the fraction of metabolisms with exaptation index I>0, and (b) the exaptation index itself, among metabolisms generated by adding a given number n _ne of non-essential reactions (x-axis) to the minimal metabolisms viable on glucose (open circles/boxes), and acetate (filled circles/boxes). Boxes span the 25-th to 75-th percentile, and whiskers indicate maxima and minima. Note that this analysis is exhaustive, meaning that (i) all minimal metabolisms viable on glucose (161), and acetate (76) are considered, and (ii) all possible n _ne -tuples of non-essential reactions (x-axis) have been added to each minimal metabolism