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. 2016 Oct 21;10:97. doi: 10.1186/s12918-016-0343-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Metabolisms can preadapt to a wide variety of carbon sources. Panels a and b show histogram of the phenotype distance (x-axis), for metabolisms of size (a) 30, and (b) 45 viable on glucose as carbon source C. c Mean phenotypic distance (coded by shade of grey, see legend) of metabolisms viable on a focal carbon source (x-axis) and with a given number of reactions n (y-axis)