Table 2.
The trend in changes of ASIA score in 64 patients with acute traumatic spinal cord injury who received progesterone and vitamin D or placebo
| Progesterone + Vitamin D (n = 32) | Placebo (n = 32) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Baseline | 6 Days | 3 Months | 6 Months | P-value* | Baseline | 6 Days | 3 Months | 6 Months | P-value* |
| Motor | ||||||||||
| Left Upper | 21.4 ± 6.9 | 23.8 ± 5.9 | 24.6 ± 8.6 | 29.6 ± 5.1δ | 0.002 | 22.4 ± 5.3 | 22.9 ± 4.3 | 23.3 ± 4.1 | 25.3 ± 3.7 | 0.061 |
| Right Upper | 21.9 ± 6.1 | 22.6 ± 7.2 | 25.9 ± 6.1 | 29.7 ± 4.9δ | 0.031 | 22.6 ± 5.9 | 22.8 ± 4.5 | 23.4 ± 6.3 | 25.6 ± 3.6 | 0.053 |
| Left Lower | 8.28 ± 2.8 | 9.43 ± 6.5 | 10.1 ± 6.4 | 17.4 ± 6.7δ | <0.001 | 9.46 ± 3.6 | 11.3 ± 9.6 | 11.5 ± 9.6 | 13.1 ± 10.2 | 0.001 |
| Right Lower | 8.65 ± 3.6 | 9.37 ± 5.9 | 10.2 ± 5.9 | 17.8 ± 8.4δ | <0.001 | 9.84 ± 5.6 | 11.4 ± 6.4 | 11.9 ± 10.7 | 13.3 ± 10.3 | 0.001 |
| Sensory | ||||||||||
| Left Upper | 35.8 ± 13.4 | 38.3 ± 14.8 | 38.3 ± 14.8 | 51.1 ± 14.2 | <0.001 | 36.3 ± 13.3 | 39.3 ± 12.5 | 41.3 ± 12.1 | 48.1 ± 7.6 | <0.001 |
| Right Upper | 33.8 ± 11.6 | 38.5 ± 14.6 | 38.5 ± 14.6 | 51.3 ± 14.1δ | <0.001 | 37.1 ± 13.2 | 39.8 ± 11.9 | 41.5 ± 11.8 | 45.6 ± 11.8 | 0.002 |
| Left Lower | 23.3 ± 17.8 | 30.6 ± 18.3 | 34.3 ± 17.8 | 39.8 ± 16.9δ | <0.001 | 21.8 ± 18.9 | 27.6 ± 20.1 | 31.2 ± 20.1 | 35.6 ± 20.7 | <0.001 |
| Right Lower | 23.2 ± 17.8 | 30.8 ± 18.3 | 34.5 ± 17.9 | 39.9 ± 16.6δ | <0.001 | 22.1 ± 17.6 | 27.1 ± 20.9 | 31.2 ± 20.2 | 35.6 ± 20.8 | <0.001 |
*p-value of less than 0.05 is considered statistically significant for trend in changes of ASIA motor and sensory scores in two different study groups.
δ Statistically higher ASIA motor or sensory score in progesterone and vitamin D group when compared to placebo group using independent t-test (p < 0.05).