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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Drug Target Rev. 2016 Jun 16;3(2):34–38.

Figure 1.

Figure 1

Reprogramming of somatic cells into iPSCs by transient expression of defined transcription factors (OCT4, SOX2, KLF4, C-MYC) is a robust and highly reproducible procedure. However, efficient and controlled multistep differentiation of iPSCs into transient phenotypes and mature functional cells and precise characterization of these cell type identities across developmental states are currently among the greatest challenges in stem cell biology.