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. Author manuscript; available in PMC: 2016 Oct 21.
Published in final edited form as: Fam Cancer. 2013 Mar;12(1):125–127. doi: 10.1007/s10689-012-9572-0

Figure 1.

Figure 1

A) Histologic features of renal tumor - typical appearances of clear cell renal cell carcinoma, characterized by nests of epithelial cells with clear cytoplasm separated by a delicate vascular network (hematoxylin and eosin, ×100). Inset - immunohistochemistry for BRCA1 shows nuclear staining in tumor cells(×100).B) 1- Results of Sanger sequencing of the kidney cancer tissue from BRCA1 mutation carrier - electropherogram shows persistence of frameshif indicating no loss of the wild type allele. 2- Results of Sanger sequencing of germline DNA from the same BRCA1 mutation carrier - electropherogram confirming the presence of BRAC1c.68- 69delAG