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. 2016 Oct 20;16:814. doi: 10.1186/s12885-016-2847-3

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — MK-0646 and MK-8669 synergistically inhibit clonogenesis. a MCF-7/AC-1 (Top) and MCF-7/AC-1/IGF-2 (Bottom) cells were exposed to increasing concentrations of MK-8669 (closed squares), MK-0646 (closed triangles) or the combination MK-8669 + MK-0646 (closed diamonds) and assessed for colony outgrowth (normalized to control). Synergy is indicated by combination index (CI) values, where < 1 is synergistic. Error bars represent SEM and results representative of three independent experiments. b Surface response modeling was employed to demonstrate the multiplicative benefit of adding MK-8669 to existing MK-0646 or vice versa. MCF-7/AC-1 cells were treated with MK-0646 (x-axis), MK-8669 (y-axis) or the combination (z-axis) at varying doses. Percent inhibition is depicted as the fraction affected (Fa)