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. 2016 Oct 21;14:71. doi: 10.1186/s12958-016-0205-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Potential effect of AGE-RAGE binding on steroidogenic enzymes. The binding of AGEs to RAGE induces several steroidogenic enzymes which might lead to increase in testosterone production. Green color represents induction. StAR: Steroidogenic Acute Regulatory protein, P450scc: cholesterol side chain cleavage enzyme, CYP17A1: 17 alpha-hydroxylase and 17, 20 lyase, and 3β-HSD: 3β hydroxysteroid dehydrogenase