Table 4.
Reference | Drug reinforcer. Dose and vehicle |
Species | Procedure/schedule | Main Results |
---|---|---|---|---|
T H C | ||||
Deneau and kaymakcalan 1971; Harris et al. 1974 |
100–400 µg/kg Tween20/salineine or 25–300 µg/kg PVP/saline |
Rhesus monkeys |
IVSA, FR1, naïve subjects | No significant acquisition |
Mansbach et al. 1994; Pickens et al. 1973 |
17–100 µg/kg in PVP/saline or EL620/EtOH/saline |
IVSA, FR1, Substitution for phencyclidine | No significant substitution | |
Carney et al. 1977; Harris et al. 1974; Kaymakcalan 1973 |
3–300 µg/kg EL620; 25–200 µg/kg PVP/saline;100–400 µg/kg Tween20/saline |
IVSA, substitution for cocaine | No significant substitution | |
Harris et al. 1974 | 25–300 µg/kg PVP/saline | IVSA, cocaine/THC combinations. Automated programmed delivery |
No significant acquisition/substitution |
|
Kaymakcalan 1973 | 100–400 µg/kg Tween20/saline | IVSA, Monkeys made dependent on THC | No significant acquisition (2 out of 6) |
|
Pickens et al. 1973 | 25 mg burned hashish | Inhalation and food presentation/FR3 and 4 sec. mouth contact to smoke tube, 24 hours per day, 4 days each week |
No significant difference from vehicle responding |
|
Li et al. 2012 | 3.2–32 µg/kg EL620/EtOH/saline | IVSA, history of heroin SA or naive | No significant acquisition | |
Corcoran and Amit 1974 | 0.25 mg (hashish)/ml | Rats | Forced drinking | No significant acquisition |
van Ree et al. 1978 | 7.5–300 µg/kg tween20/saline | IVSA, naïve | 40% positive | |
Takahashi and Singer 1979; 1980 | 6.25–50 µg/kg tween80/saline | IVSA, naïve, food deprived, with automatic food pellet delivery |
Positive results maintained only with food deprivation and pellet delivery |
|
Braida et al. 2004 | 0.01–1 µg/inf cerebrospinal fluid, EtOH, cremophor |
ICVSA, trained with water | Positive results, max responding at 0.02 µg/inf |
|
Tanda et al. 2000; Justinova et al. 2008; Justinova et al. 2003 |
1–16 µg/kg EtOH/Tween80/saline | Squirrel monkeys |
IVSA, naïve or cocaine trained with saline extinction/FR or second order |
Positive results, max responding at 4 µg/kg |
Anandamide and Methanandamide | ||||
Justinova et al. 2005 | 2.5–160 µg/kg tween80/saline/eth | Squirrel monkeys |
FR10, IVSA, drug naïve | Positive results, max responding at 40 µg/kg |
2-AG | ||||
De Luca et al. 2014 | 12.5–50 µg/kg tween80/saline/eth | Sprague Dawley Rats |
IVSA, naïve | 90% positive, max responding at 25 µg/kg |
Justinova et al. 2011 | 0.1–100 µg/kg EtOH/Tween80/saline | Squirrel monkeys |
IVSA, nicotine substitution or history IVSA of anandamide, anandamide reuptake inhibitors or nicotine |
100% positive, max responding at 3 µg/kg |
CP55,940 | ||||
Mansbach et al. 1994 | 0.3–3 µg/kg emulphor/ EtOH/saline | Rhesus monkey |
IVSA,PCP substitution | No acquisition |
Braida et al. 2001 | 0.1–1.6 µg cerebrospinal fluid, EtOH, cremophor |
Wistar Rats |
IVSA | Positive, max responding at 0.4 µg/kg |
WIN55,212-2 | ||||
Martellotta et al. 1998 | 10–500 µg/kg ? | CD1 Mice | IVSA, naïve | Positive, max responding at 100 µg/kg |
Fattore et al. 2001 | 6.25–50 µg/kg Tween 80/heparin/saline |
Wistar Rats |
IVSA, naïve | 87% positive, max responding at 12.5 µg/kg |
Solinas et al. 2007 | 12.5–25 µg/kg Tween 80/saline | Long– Evans Rats |
Positive, max responding at 12.5 µg/kg |
|
Justinova et al 2013 | 12.5 µg/kg Tween- 80/heparin/saline | Long– Evans Rats/Spra gue Dawley |
IVSA, naïve | Positive |
Lecca et al. 2006 | 12.5 µg/kg Tween 80/saline | Sprague Dawley Rats |
IVSA, naïve | Positive |
JWH 018 | ||||
De Luca et al. 2015 | 10–20 µg/kg EtOH/Tween80/saline | Sprague– Dawley Rats |
IVSA, naïve | 90% positive, max responding at 20 µg/kg |
De Luca et al. 2015 | 15–30 µg/kg EtOH/Tween80/saline | C57BL/6 mice |
IVSA, naïve | 90% positive, at 30 µg/kg |
IVSA = intravenous self-administration