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Large condition number of the cell proportion matrix negatively affects stability of sensitivity. Cell proportion matrixes were simulated to obtain condition numbers 100, 200, 500, 1000, 5000, 10000, 25000, 50000, and 75000. Each condition number was simulated 100 times by small perturbations of the cell proportion values. The following parameters were held constant: SD for the target cell proportion – 0.2, per-group sample size – 10, MSE – 0.1, cell type-specific effect size – 0.1
